Path ID: DB01280_MESH_D054218_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C104457 | nelarabine | Drug |
| MESH:C022206 | 9-beta-D-arabinofuranosylguanosine 5’-triphosphate | ChemicalSubstance |
| UniProt:P09884 | DNA polymerase alpha catalytic subunit | Protein |
| GO:0090592 | DNA synthesis involved in DNA replication | BiologicalProcess |
| GO:0006260 | DNA replication | BiologicalProcess |
| HP:0031379 | Abnormal T cell proliferation | PhenotypicFeature |
| MESH:D054218 | T-cell acute lymphoblastic leukemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Nelarabine | PRODUCES | 9-Beta-D-Arabinofuranosylguanosine 5’-Triphosphate |
| 9-Beta-D-Arabinofuranosylguanosine 5’-Triphosphate | DECREASES ACTIVITY OF | Dna Polymerase Alpha Catalytic Subunit |
| Dna Polymerase Alpha Catalytic Subunit | POSITIVELY REGULATES | Dna Replication |
| Dna Replication | POSITIVELY CORRELATED WITH | Abnormal T Cell Proliferation |
| 9-Beta-D-Arabinofuranosylguanosine 5’-Triphosphate | PREVENTS | Dna Synthesis Involved In Dna Replication |
| Dna Synthesis Involved In Dna Replication | POSITIVELY CORRELATED WITH | Abnormal T Cell Proliferation |
| Abnormal T Cell Proliferation | POSITIVELY CORRELATED WITH | T-Cell Acute Lymphoblastic Leukemia |
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