Path ID: DB01266_MESH_D003218_1

Concepts
| Identifier | Name | Type |
|---|---|---|
| DB:DB01266 | Sinecatechins | Drug |
| InterPro:IPR047096 | Nuclear factor NF-kappa-B p105 subunit, death domain | GeneFamily |
| InterPro:IPR000837 | AP-1 transcription factor | GeneFamily |
| InterPro:IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain | GeneFamily |
| InterPro:IPR003545 | Telomerase reverse transcriptase | GeneFamily |
| UniProt:P03129 | Protein E7 | Protein |
| InterPro:IPR002117 | p53 tumour suppressor family | GeneFamily |
| InterPro:IPR028309 | Retinoblastoma protein family | GeneFamily |
| GO:0051301 | cell division | BiologicalProcess |
| taxonomy:10566 | Human papillomavirus | OrganismTaxon |
| MESH:D003218 | Condylomata Acuminata | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Sinecatechins | DECREASES ACTIVITY OF | Nuclear Factor Nf-Kappa-B P105 Subunit, Death Domain |
| Sinecatechins | DECREASES ACTIVITY OF | Ap-1 Transcription Factor |
| Sinecatechins | DECREASES ACTIVITY OF | Serine-Threonine/Tyrosine-Protein Kinase, Catalytic Domain |
| Sinecatechins | DECREASES ACTIVITY OF | Telomerase Reverse Transcriptase |
| Sinecatechins | DECREASES ACTIVITY OF | Protein E7 |
| Sinecatechins | INCREASES ACTIVITY OF | P53 Tumour Suppressor Family |
| Sinecatechins | INCREASES ACTIVITY OF | Retinoblastoma Protein Family |
| Nuclear Factor Nf-Kappa-B P105 Subunit, Death Domain | POSITIVELY REGULATES | Cell Division |
| Ap-1 Transcription Factor | POSITIVELY REGULATES | Cell Division |
| Serine-Threonine/Tyrosine-Protein Kinase, Catalytic Domain | POSITIVELY REGULATES | Cell Division |
| Telomerase Reverse Transcriptase | POSITIVELY REGULATES | Cell Division |
| Protein E7 | POSITIVELY REGULATES | Cell Division |
| P53 Tumour Suppressor Family | NEGATIVELY REGULATES | Cell Division |
| Retinoblastoma Protein Family | NEGATIVELY REGULATES | Cell Division |
| Cell Division | IN TAXON | Human Papillomavirus |
| Human Papillomavirus | CAUSES | Condylomata Acuminata |
Reference:
- https://go.drugbank.com/drugs/DB01266#mechanism-of-action
- https://en.wikipedia.org/wiki/Sinecatechins
- https://www.uniprot.org/uniprot/P03129#function
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277090/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066610/
- https://en.wikipedia.org/wiki/Genital_wart