Path ID: DB01260_MESH_D011538_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D003898 | desonide | Drug |
| UniProt:P04150 | Glucocorticoid receptor | Protein |
| UniProt:P47712 | Cytosolic phospholipase A2 | Protein |
| GO:0019370 | leukotriene biosynthetic process | BiologicalProcess |
| GO:0001516 | prostaglandin biosynthetic process | BiologicalProcess |
| GO:0006954 | inflammatory response | BiologicalProcess |
| HP:0000989 | Pruritus | PhenotypicFeature |
| UBERON:0001245 | anus | GrossAnatomicalStructure |
| MESH:D011538 | Pruritus Ani | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Desonide | INCREASES ACTIVITY OF | Glucocorticoid Receptor |
| Glucocorticoid Receptor | DECREASES ABUNDANCE OF | Cytosolic Phospholipase A2 |
| Cytosolic Phospholipase A2 | POSITIVELY REGULATES | Leukotriene Biosynthetic Process |
| Cytosolic Phospholipase A2 | POSITIVELY REGULATES | Prostaglandin Biosynthetic Process |
| Leukotriene Biosynthetic Process | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Prostaglandin Biosynthetic Process | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Pruritus |
| Pruritus | LOCATED IN | Anus |
| Anus | LOCATION OF | Pruritus Ani |
Reference: