Path ID: DB01255_MESH_D001289_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000069478 | lisdexamfetamine | Drug |
| MESH:D003913 | Dextroamphetamine | ChemicalSubstance |
| UniProt:P23975 | Sodium-dependent noradrenaline transporter | Protein |
| GO:0051620 | Norepinephrine uptake | BiologicalProcess |
| MESH:D009638 | Norepinephrine | ChemicalSubstance |
| UniProt:Q01959 | Sodium-dependent dopamine transporter | Protein |
| GO:0051583 | Dopamine uptake involved in synaptic transmission | BiologicalProcess |
| MESH:D004298 | Dopamine | ChemicalSubstance |
| GO:0061527 | Dopamine secretion, neurotransmission | BiologicalProcess |
| UniProt:Q05940 | Synaptic vesicular amine transporter | Protein |
| GO:0015842 | Aminergic neurotransmitter loading into synaptic vesicle | BiologicalProcess |
| GO:0061533 | Norepinephrine secretion, neurotransmission | BiologicalProcess |
| MESH:D001289 | Attention deficit hyperactivity disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Lisdexamfetamine | HAS METABOLITE | Dextroamphetamine |
| Dextroamphetamine | DECREASES ACTIVITY OF | Sodium-Dependent Noradrenaline Transporter |
| Dextroamphetamine | DECREASES ACTIVITY OF | Sodium-Dependent Dopamine Transporter |
| Dextroamphetamine | DECREASES ACTIVITY OF | Synaptic Vesicular Amine Transporter |
| Sodium-Dependent Noradrenaline Transporter | POSITIVELY REGULATES | Norepinephrine Uptake |
| Norepinephrine Uptake | DECREASES ABUNDANCE OF | Norepinephrine |
| Sodium-Dependent Dopamine Transporter | POSITIVELY REGULATES | Dopamine Uptake Involved In Synaptic Transmission |
| Dopamine Uptake Involved In Synaptic Transmission | DECREASES ABUNDANCE OF | Dopamine |
| Dopamine | POSITIVELY CORRELATED WITH | Dopamine Secretion, Neurotransmission |
| Synaptic Vesicular Amine Transporter | POSITIVELY REGULATES | Aminergic Neurotransmitter Loading Into Synaptic Vesicle |
| Aminergic Neurotransmitter Loading Into Synaptic Vesicle | DECREASES ABUNDANCE OF | Dopamine |
| Aminergic Neurotransmitter Loading Into Synaptic Vesicle | DECREASES ABUNDANCE OF | Norepinephrine |
| Norepinephrine | POSITIVELY CORRELATED WITH | Norepinephrine Secretion, Neurotransmission |
| Dopamine | POSITIVELY CORRELATED WITH | Dopamine Secretion, Neurotransmission |
| Norepinephrine Secretion, Neurotransmission | TREATS | Attention Deficit Hyperactivity Disorder |
| Dopamine Secretion, Neurotransmission | TREATS | Attention Deficit Hyperactivity Disorder |
Comment: Lisdexamfetamine is a prodrug of dextroamphetamine. The active form of this drug blocks the reuptake of norepinephrine and dopamine into the presynaptic neuron and increase the release of these monoamines into the extraneuronal space.
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