Path ID: DB01244_MESH_D000787_4
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D015764 | Bepridil | Drug |
| UniProt:O95180 | Voltage-dependent T-type calcium channel subunit alpha-1H | Protein |
| GO:0070509 | calcium ion import | BiologicalProcess |
| GO:0086046 | membrane depolarization during SA node cell action potential | BiologicalProcess |
| GO:0060047 | heart contraction | BiologicalProcess |
| MESH:D017202 | Myocardial Ischemia | PhenotypicFeature |
| MESH:D000787 | Angina pectoris | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Bepridil | NEGATIVELY REGULATES | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1H |
| Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1H | POSITIVELY CORRELATED WITH | Calcium Ion Import |
| Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1H | POSITIVELY CORRELATED WITH | Membrane Depolarization During Sa Node Cell Action Potential |
| Calcium Ion Import | POSITIVELY REGULATES | Heart Contraction |
| Membrane Depolarization During Sa Node Cell Action Potential | POSITIVELY REGULATES | Heart Contraction |
| Heart Contraction | NEGATIVELY CORRELATED WITH | Myocardial Ischemia |
| Myocardial Ischemia | POSITIVELY CORRELATED WITH | Angina Pectoris |
Reference: