Path ID: DB01235_MESH_D020734_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D007980 | levodopa | Drug |
| MESH:D004295 | Dihydroxyphenylalanine | ChemicalSubstance |
| UniProt:P35462 | D(3) dopamine receptor | Protein |
| GO:0001963 | synaptic transmission, dopaminergic | BiologicalProcess |
| MESH:D020734 | Parkinsonism | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Levodopa | HAS METABOLITE | Dihydroxyphenylalanine |
| Dihydroxyphenylalanine | POSITIVELY REGULATES | D(3) Dopamine Receptor |
| D(3) Dopamine Receptor | POSITIVELY REGULATES | Synaptic Transmission, Dopaminergic |
| Synaptic Transmission, Dopaminergic | NEGATIVELY CORRELATED WITH | Parkinsonism |
Comment: It’s been debated whether the side effects of this drug is worth it when used for treating Parkinson’s (https://en.wikipedia.org/wiki/Dopamine_agonist#History).
Reference: