Path ID: DB01234_MESH_D000312_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D003907 | dexamethasone | Drug |
| UniProt:P04150 | Glucocorticoid receptor | Protein |
| GO:0006702 | androgen biosynthetic process | BiologicalProcess |
| MESH:D000312 | Adrenogenital disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dexamethasone | POSITIVELY REGULATES | Glucocorticoid Receptor |
| Glucocorticoid Receptor | NEGATIVELY CORRELATED WITH | Androgen Biosynthetic Process |
| Androgen Biosynthetic Process | POSITIVELY CORRELATED WITH | Adrenogenital Disorder |
Comment: Glucocorticoids suppress adrenal androgen synthesis through a negative feedback on the pituitary gland (https://amj.amegroups.com/article/view/4506/5248).
Reference: