Path ID: DB01233_MESH_D005764_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008787 | Metoclopramide | Drug |
| UniProt:P14416 | D2 dopamine receptor | Protein |
| UniProt:P11229 | Muscarinic acetylcholine receptor M1 | Protein |
| UniProt:Q13639 | 5-hydroxytryptamine receptor 4 | Protein |
| GO:0014055 | Acetylcholine secretion, neurotransmission | BiologicalProcess |
| UBERON:0007652 | Esophageal sphincter | GrossAnatomicalStructure |
| GO:0035482 | Gastric motility | BiologicalProcess |
| GO:0035483 | Gastric emptying | BiologicalProcess |
| MESH:D005764 | Gastroesophageal reflux disease | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Metoclopramide | DECREASES ACTIVITY OF | D2 Dopamine Receptor |
| Metoclopramide | INCREASES ACTIVITY OF | Muscarinic Acetylcholine Receptor M1 |
| Metoclopramide | INCREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 4 |
| D2 Dopamine Receptor | NEGATIVELY REGULATES | Acetylcholine Secretion, Neurotransmission |
| Muscarinic Acetylcholine Receptor M1 | POSITIVELY REGULATES | Acetylcholine Secretion, Neurotransmission |
| 5-Hydroxytryptamine Receptor 4 | POSITIVELY REGULATES | Acetylcholine Secretion, Neurotransmission |
| Acetylcholine Secretion, Neurotransmission | POSITIVELY REGULATES | Esophageal Sphincter |
| Acetylcholine Secretion, Neurotransmission | POSITIVELY REGULATES | Gastric Motility |
| Esophageal Sphincter | NEGATIVELY REGULATES | Gastroesophageal Reflux Disease |
| Gastric Motility | POSITIVELY REGULATES | Gastric Emptying |
| Gastric Emptying | NEGATIVELY CORRELATED WITH | Gastroesophageal Reflux Disease |
Reference: