Path ID: DB01229_MESH_D012514_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| DB:DB01229 | Paclitaxel | Drug |
| UniProt:Q9H4B7 | Tubulin beta-1 chain | Protein |
| UniProt:P10415 | Apoptosis regulator Bcl-2 | Protein |
| GO:0006915 | Apoptotic process | BiologicalProcess |
| GO:0051225 | Spindle assembly | BiologicalProcess |
| GO:0000278 | Mitotic cell cycle | BiologicalProcess |
| GO:0008283 | Cell population proliferation | BiologicalProcess |
| MESH:D012514 | Kaposi’s sarcoma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Paclitaxel | DECREASES ACTIVITY OF | Tubulin Beta-1 Chain |
| Paclitaxel | DECREASES ACTIVITY OF | Apoptosis Regulator Bcl-2 |
| Tubulin Beta-1 Chain | PARTICIPATES IN | Spindle Assembly |
| Apoptosis Regulator Bcl-2 | NEGATIVELY REGULATES | Apoptotic Process |
| Apoptotic Process | NEGATIVELY CORRELATED WITH | Kaposi’S Sarcoma |
| Spindle Assembly | POSITIVELY CORRELATED WITH | Mitotic Cell Cycle |
| Mitotic Cell Cycle | POSITIVELY CORRELATED WITH | Cell Population Proliferation |
| Cell Population Proliferation | POSITIVELY CORRELATED WITH | Kaposi’S Sarcoma |
Comment: Paclitaxel should not be given to patients with AIDS-related Kaposi’s sarcoma if the baseline neutrophil count is less than 1000 cells/mm3.
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