Path ID: DB01228_MESH_D018879_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D016700 | encainide | Drug |
| InterPro:IPR001696 | Voltage gated sodium channel, alpha subunit | GeneFamily |
| GO:0086060 | voltage-gated sodium channel activity involved in AV node cell action potential | MolecularActivity |
| GO:0061337 | cardiac conduction | BiologicalProcess |
| GO:0060047 | heart contraction | BiologicalProcess |
| HP:0001649 | heart rate | PhenotypicFeature |
| HP:0000822 | blood pressure | PhenotypicFeature |
| MESH:D018879 | Ventricular premature beats | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Encainide | DECREASES ACTIVITY OF | Voltage Gated Sodium Channel, Alpha Subunit |
| Voltage Gated Sodium Channel, Alpha Subunit | POSITIVELY REGULATES | Voltage-Gated Sodium Channel Activity Involved In Av Node Cell Action Potential |
| Voltage-Gated Sodium Channel Activity Involved In Av Node Cell Action Potential | POSITIVELY REGULATES | Cardiac Conduction |
| Cardiac Conduction | POSITIVELY REGULATES | Heart Contraction |
| Heart Contraction | POSITIVELY CORRELATED WITH | Heart Rate |
| Heart Contraction | POSITIVELY CORRELATED WITH | Blood Pressure |
| Heart Rate | POSITIVELY CORRELATED WITH | Ventricular Premature Beats |
| Blood Pressure | POSITIVELY CORRELATED WITH | Ventricular Premature Beats |
Comment: Encainide (trade name Enkaid) is a class Ic antiarrhythmic agent. It is no longer used because of its frequent proarrhythmic side effects.
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