Path ID: DB01224_MESH_D012559_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000069348 | quetiapine | Drug |
| UniProt:P28223 | 5-hydroxytryptamine receptor 2A | Protein |
| UniProt:P14416 | D(2) dopamine receptor | Protein |
| GO:0014046 | dopamine secretion | BiologicalProcess |
| CHEBI:18243 | dopamine | ChemicalSubstance |
| UBERON:0009834 | dorsolateral prefrontal cortex | GrossAnatomicalStructure |
| UBERON:0001910 | medial forebrain bundle | GrossAnatomicalStructure |
| HP:0100543 | Cognitive impairment | PhenotypicFeature |
| HP:0030213 | Emotional blunting | PhenotypicFeature |
| HP:0012154 | Anhedonia | PhenotypicFeature |
| HP:0002465 | Poor speech | PhenotypicFeature |
| HP:0000741 | Apathy | PhenotypicFeature |
| HP:0000709 | Psychosis | PhenotypicFeature |
| MESH:D012559 | Schizophrenia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Quetiapine | DECREASES ACTIVITY OF | D(2) Dopamine Receptor |
| Quetiapine | DECREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 2A |
| 5-Hydroxytryptamine Receptor 2A | POSITIVELY REGULATES | Dopamine Secretion |
| D(2) Dopamine Receptor | POSITIVELY REGULATES | Dopamine Secretion |
| Dopamine Secretion | INCREASES ABUNDANCE OF | Dopamine |
| Dopamine | LOCATED IN | Medial Forebrain Bundle |
| Medial Forebrain Bundle | CORRELATED WITH | Psychosis |
| Psychosis | POSITIVELY CORRELATED WITH | Schizophrenia |
| Dopamine | LOCATED IN | Dorsolateral Prefrontal Cortex |
| Dorsolateral Prefrontal Cortex | CORRELATED WITH | Cognitive Impairment |
| Dorsolateral Prefrontal Cortex | CORRELATED WITH | Emotional Blunting |
| Dorsolateral Prefrontal Cortex | CORRELATED WITH | Anhedonia |
| Dorsolateral Prefrontal Cortex | CORRELATED WITH | Poor Speech |
| Dorsolateral Prefrontal Cortex | CORRELATED WITH | Apathy |
| Cognitive Impairment | POSITIVELY CORRELATED WITH | Schizophrenia |
| Emotional Blunting | POSITIVELY CORRELATED WITH | Schizophrenia |
| Anhedonia | POSITIVELY CORRELATED WITH | Schizophrenia |
| Poor Speech | POSITIVELY CORRELATED WITH | Schizophrenia |
| Apathy | POSITIVELY CORRELATED WITH | Schizophrenia |
Reference: