Path ID: DB01224_MESH_D001714_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000069348 | quetiapine | Drug |
| UniProt:P23975 | Sodium-dependent noradrenaline transporter | Protein |
| GO:0051620 | norepinephrine uptake | BiologicalProcess |
| HP:0000716 | Depressivity | PhenotypicFeature |
| HP:0100754 | Mania | PhenotypicFeature |
| MESH:D001714 | Bipolar Disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Quetiapine | DECREASES ACTIVITY OF | Sodium-Dependent Noradrenaline Transporter |
| Sodium-Dependent Noradrenaline Transporter | POSITIVELY REGULATES | Norepinephrine Uptake |
| Norepinephrine Uptake | POSITIVELY CORRELATED WITH | Depressivity |
| Norepinephrine Uptake | POSITIVELY CORRELATED WITH | Mania |
| Depressivity | MANIFESTATION OF | Bipolar Disorder |
| Mania | MANIFESTATION OF | Bipolar Disorder |
Reference: