Path ID: DB01219_MESH_D009128_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D003620 | Dantrolene | Drug |
| UniProt:P21817 | Ryanodine receptor 1 | Protein |
| GO:1990425 | Ryanodine receptor complex | CellularComponent |
| GO:0005219 | ryanodine-sensitive calcium-release channel activity | MolecularActivity |
| GO:0032470 | positive regulation of endoplasmic reticulum calcium ion concentration | BiologicalProcess |
| GO:0006936 | muscle contraction | BiologicalProcess |
| MESH:D009128 | Spasticity | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dantrolene | NEGATIVELY REGULATES | Ryanodine Receptor 1 |
| Ryanodine Receptor 1 | PART OF | Ryanodine Receptor Complex |
| Ryanodine Receptor Complex | PARTICIPATES IN | Ryanodine-Sensitive Calcium-Release Channel Activity |
| Ryanodine-Sensitive Calcium-Release Channel Activity | PARTICIPATES IN | Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration |
| Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration | PARTICIPATES IN | Muscle Contraction |
| Muscle Contraction | REGULATES | Spasticity |
Reference: