Path ID: DB01204_MESH_D020529_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008942 | Mitoxantrone | Drug |
| MESH:D004247 | DNA | ChemicalSubstance |
| UniProt:P11388 | DNA topoisomerase 2-alpha | Protein |
| CL:0000084 | T cell | Cell |
| CL:0000236 | B cell | Cell |
| CL:0000145 | Professional antigen presenting cell | Cell |
| CL:0000235 | Macrophage | Cell |
| MESH:D020529 | Relapsing remitting multiple sclerosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Mitoxantrone | DISRUPTS | Dna |
| Mitoxantrone | NEGATIVELY REGULATES | Dna Topoisomerase 2-Alpha |
| Dna | OCCURS IN | T Cell |
| Dna Topoisomerase 2-Alpha | OCCURS IN | T Cell |
| Dna | OCCURS IN | B Cell |
| Dna Topoisomerase 2-Alpha | OCCURS IN | B Cell |
| Dna | OCCURS IN | Professional Antigen Presenting Cell |
| Dna Topoisomerase 2-Alpha | OCCURS IN | Professional Antigen Presenting Cell |
| Dna | OCCURS IN | Macrophage |
| Dna Topoisomerase 2-Alpha | OCCURS IN | Macrophage |
| T Cell | POSITIVELY CORRELATED WITH | Relapsing Remitting Multiple Sclerosis |
| B Cell | POSITIVELY CORRELATED WITH | Relapsing Remitting Multiple Sclerosis |
| Professional Antigen Presenting Cell | POSITIVELY CORRELATED WITH | Relapsing Remitting Multiple Sclerosis |
| Macrophage | POSITIVELY CORRELATED WITH | Relapsing Remitting Multiple Sclerosis |
Reference: