Path ID: DB01191_MESH_D009765_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D020372 | dexfenfluramine | Drug |
| UniProt:P28335 | 5-hydroxytryptamine receptor 2C | Protein |
| reactome:R-HSA-416476 | G alpha (q) signalling events | Pathway |
| GO:0007631 | feeding behavior | BiologicalProcess |
| GO:0032098 | regulation of appetite | BiologicalProcess |
| MESH:D009765 | Obesity | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dexfenfluramine | POSITIVELY REGULATES | 5-Hydroxytryptamine Receptor 2C |
| 5-Hydroxytryptamine Receptor 2C | PARTICIPATES IN | G Alpha (Q) Signalling Events |
| G Alpha (Q) Signalling Events | POSITIVELY REGULATES | Feeding Behavior |
| G Alpha (Q) Signalling Events | POSITIVELY REGULATES | Regulation Of Appetite |
| Feeding Behavior | POSITIVELY CORRELATED WITH | Obesity |
| Regulation Of Appetite | NEGATIVELY CORRELATED WITH | Obesity |
Comment: FDA has withdrawn the approval for marketing this drug as per its cardiovascular side-effects.
Reference: