Path ID: DB01191_MESH_D009765_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D020372 | dexfenfluramine | Drug |
| UniProt:P31645 | Sodium-dependent serotonin transporter | Protein |
| GO:0051610 | serotonin uptake | BiologicalProcess |
| HP:0100738 | Abnormal eating behavior | PhenotypicFeature |
| MESH:D009765 | Obesity | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dexfenfluramine | NEGATIVELY REGULATES | Sodium-Dependent Serotonin Transporter |
| Sodium-Dependent Serotonin Transporter | POSITIVELY REGULATES | Serotonin Uptake |
| Serotonin Uptake | AFFECTS RISK FOR | Abnormal Eating Behavior |
| Abnormal Eating Behavior | POSITIVELY CORRELATED WITH | Obesity |
Comment: FDA has withdrawn the approval for marketing this drug as per its cardiovascular side-effects.
Reference: