Path ID: DB01179_MESH_D003218_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D011034 | podophyllotoxin | Drug |
| UniProt:P03120 | Regulatory protein E2 | Protein |
| GO:0039693 | viral DNA genome replication | BiologicalProcess |
| taxonomy:10566 | Human papillomavirus | OrganismTaxon |
| MESH:D003218 | Condyloma acuminatum | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Podophyllotoxin | NEGATIVELY REGULATES | Regulatory Protein E2 |
| Regulatory Protein E2 | POSITIVELY REGULATES | Viral Dna Genome Replication |
| Viral Dna Genome Replication | IN TAXON | Human Papillomavirus |
| Human Papillomavirus | CAUSES | Condyloma Acuminatum |
Comment: This drug can also inhbit human proteins and affect with the mammalian cell division/replication, which make them an attractive antitumour agent (https://pubmed.ncbi.nlm.nih.gov/11102564/).
Reference: