Path ID: DB01170_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D006145 | Guanethidine | Drug |
| UniProt:P23975 | Sodium-dependent noradrenaline transporter | Protein |
| MESH:D009638 | Norepinephrine | ChemicalSubstance |
| GO:0042310 | Vasoconstriction | BiologicalProcess |
| GO:0048243 | Norepinephrine secretion | BiologicalProcess |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Guanethidine | MOLECULARLY INTERACTS WITH | Sodium-Dependent Noradrenaline Transporter |
| Sodium-Dependent Noradrenaline Transporter | DECREASES ABUNDANCE OF | Norepinephrine |
| Norepinephrine | POSITIVELY REGULATES | Vasoconstriction |
| Guanethidine | NEGATIVELY REGULATES | Norepinephrine Secretion |
| Norepinephrine Secretion | POSITIVELY CORRELATED WITH | Norepinephrine |
| Vasoconstriction | POSITIVELY CORRELATED WITH | Hypertensive Disorder |
Reference: