Path ID: DB01169_MESH_D015479_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C006632 | arsenic trioxide | Drug |
| MESH:D015514 | Oncogene Proteins, Fusion | Protein |
| CHEBI:26523 | reactive oxygen species | ChemicalSubstance |
| GO:0071838 | cell proliferation in bone marrow | BiologicalProcess |
| GO:0001525 | angiogenesis | BiologicalProcess |
| GO:0006309 | apoptotic DNA fragmentation | BiologicalProcess |
| MESH:D015479 | Acute myelomonocytic leukemia, FAB M4 | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Arsenic Trioxide | NEGATIVELY CORRELATED WITH | Cell Proliferation In Bone Marrow |
| Cell Proliferation In Bone Marrow | POSITIVELY CORRELATED WITH | Acute Myelomonocytic Leukemia, Fab M4 |
| Arsenic Trioxide | NEGATIVELY CORRELATED WITH | Angiogenesis |
| Angiogenesis | POSITIVELY CORRELATED WITH | Acute Myelomonocytic Leukemia, Fab M4 |
| Arsenic Trioxide | INCREASES ABUNDANCE OF | Reactive Oxygen Species |
| Reactive Oxygen Species | POSITIVELY CORRELATED WITH | Apoptotic Dna Fragmentation |
| Arsenic Trioxide | DISRUPTS | Oncogene Proteins, Fusion |
| Oncogene Proteins, Fusion | POSITIVELY CORRELATED WITH | Acute Myelomonocytic Leukemia, Fab M4 |
| Apoptotic Dna Fragmentation | NEGATIVELY CORRELATED WITH | Acute Myelomonocytic Leukemia, Fab M4 |
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