Path ID: DB01166_MESH_D007383_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C045645 | cilostazol | Drug |
| UniProt:Q14432 | cGMP-inhibited 3’,5’-cyclic phosphodiesterase A | Protein |
| GO:0004115 | 3’,5’-cyclic-AMP phosphodiesterase activity | MolecularActivity |
| CHEBI:17489 | 3’,5’-cyclic AMP | ChemicalSubstance |
| MESH:D017868 | Cyclic AMP-Dependent Protein Kinases | GeneFamily |
| GO:0070527 | platelet aggregation | BiologicalProcess |
| GO:0042311 | vasodilation | BiologicalProcess |
| MESH:D007383 | Intermittent claudication | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Cilostazol | NEGATIVELY REGULATES | Cgmp-Inhibited 3’,5’-Cyclic Phosphodiesterase A |
| Cgmp-Inhibited 3’,5’-Cyclic Phosphodiesterase A | POSITIVELY REGULATES | 3’,5’-Cyclic-Amp Phosphodiesterase Activity |
| 3’,5’-Cyclic-Amp Phosphodiesterase Activity | DECREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| 3’,5’-Cyclic Amp | INCREASES ACTIVITY OF | Cyclic Amp-Dependent Protein Kinases |
| Cyclic Amp-Dependent Protein Kinases | POSITIVELY CORRELATED WITH | Vasodilation |
| Cyclic Amp-Dependent Protein Kinases | NEGATIVELY CORRELATED WITH | Platelet Aggregation |
| Vasodilation | NEGATIVELY CORRELATED WITH | Intermittent Claudication |
| Platelet Aggregation | POSITIVELY CORRELATED WITH | Intermittent Claudication |
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