Path ID: DB01156_MESH_D003866_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D016642 | bupropion | Drug |
| UniProt:P23975 | Sodium-dependent noradrenaline transporter | Protein |
| GO:0051620 | norepinephrine uptake | BiologicalProcess |
| MESH:D009638 | Noradrenaline | ChemicalSubstance |
| UniProt:Q01959 | Sodium-dependent dopamine transporter | Protein |
| GO:0090494 | dopamine uptake | BiologicalProcess |
| MESH:D004298 | Dopamine | ChemicalSubstance |
| MESH:D003866 | Depressive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Bupropion | DECREASES ACTIVITY OF | Sodium-Dependent Noradrenaline Transporter |
| Sodium-Dependent Noradrenaline Transporter | POSITIVELY REGULATES | Norepinephrine Uptake |
| Norepinephrine Uptake | DECREASES ABUNDANCE OF | Noradrenaline |
| Noradrenaline | POSITIVELY CORRELATED WITH | Depressive Disorder |
| Bupropion | DECREASES ACTIVITY OF | Sodium-Dependent Dopamine Transporter |
| Sodium-Dependent Dopamine Transporter | POSITIVELY REGULATES | Dopamine Uptake |
| Dopamine Uptake | DECREASES ABUNDANCE OF | Dopamine |
| Dopamine | POSITIVELY CORRELATED WITH | Depressive Disorder |
Reference: