Path ID: DB01144_MESH_D015812_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004005 | dichlorphenamide | Drug |
| UniProt:P00915 | Carbonic anhydrase 1 | Protein |
| UniProt:P00918 | Carbonic anhydrase 2 | Protein |
| UniProt:P22748 | Carbonic anhydrase 4 | Protein |
| UniProt:P43166 | Carbonic anhydrase 7 | Protein |
| UniProt:O43570 | Carbonic anhydrase 12 | Protein |
| GO:0015701 | bicarbonate transport | BiologicalProcess |
| UBERON:0001796 | aqueous humor of eyeball | GrossAnatomicalStructure |
| HP:0007906 | Ocular Hypertension | PhenotypicFeature |
| MESH:D015812 | Angle-closure glaucoma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dichlorphenamide | NEGATIVELY REGULATES | Carbonic Anhydrase 1 |
| Dichlorphenamide | NEGATIVELY REGULATES | Carbonic Anhydrase 2 |
| Dichlorphenamide | NEGATIVELY REGULATES | Carbonic Anhydrase 4 |
| Dichlorphenamide | NEGATIVELY REGULATES | Carbonic Anhydrase 7 |
| Dichlorphenamide | NEGATIVELY REGULATES | Carbonic Anhydrase 12 |
| Carbonic Anhydrase 1 | POSITIVELY REGULATES | Bicarbonate Transport |
| Carbonic Anhydrase 2 | POSITIVELY REGULATES | Bicarbonate Transport |
| Carbonic Anhydrase 4 | POSITIVELY REGULATES | Bicarbonate Transport |
| Carbonic Anhydrase 7 | POSITIVELY REGULATES | Bicarbonate Transport |
| Carbonic Anhydrase 12 | POSITIVELY REGULATES | Bicarbonate Transport |
| Bicarbonate Transport | INCREASES ABUNDANCE OF | Aqueous Humor Of Eyeball |
| Aqueous Humor Of Eyeball | POSITIVELY CORRELATED WITH | Ocular Hypertension |
| Ocular Hypertension | POSITIVELY CORRELATED WITH | Angle-Closure Glaucoma |
Reference:
- https://go.drugbank.com/drugs/DB01144#mechanism-of-action
- https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL17/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC506660/
- [https://en.wikipedia.org/wiki/Glaucoma#Medication](https://en.wikipedia.org/wiki/Glaucoma#Medication)
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC506660/
- https://www.aaopt.org/docs/knowledge-base/outline26514.doc?sfvrsn=5f863d3_0
- https://en.wikipedia.org/wiki/Aqueous_humour#Clinical_significance