Path ID: DB01131_MESH_D016778_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D002727 | Proguanil | Drug |
| MESH:C026009 | cycloguanil | ChemicalSubstance |
| UniProt:P00374 | Dihydrofolate reductase | Protein |
| reactome:R-HSA-8956320 | Nucleotide biosynthesis | Pathway |
| GO:0071897 | DNA biosynthetic process | BiologicalProcess |
| taxonomy:5833 | Plasmodium falciparum | OrganismTaxon |
| MESH:D016778 | Malaria, Falciparum | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Proguanil | HAS METABOLITE | Cycloguanil |
| Cycloguanil | DECREASES ACTIVITY OF | Dihydrofolate Reductase |
| Dihydrofolate Reductase | POSITIVELY REGULATES | Nucleotide Biosynthesis |
| Nucleotide Biosynthesis | POSITIVELY REGULATES | Dna Biosynthetic Process |
| Dna Biosynthetic Process | IN TAXON | Plasmodium Falciparum |
| Plasmodium Falciparum | CAUSES | Malaria, Falciparum |
Reference: