Path ID: DB01124_MESH_D003924_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014044 | Tolbutamide | Drug |
| UniProt:Q09428 | ATP-binding cassette sub-family C member 8 | Protein |
| GO:0015272 | ATP-activated inward rectifier potassium channel activity | BiologicalProcess |
| GO:0051899 | Membrane depolarization | BiologicalProcess |
| GO:0070509 | Calcium ion import | BiologicalProcess |
| GO:0030073 | Insulin secretion | BiologicalProcess |
| HP:0003074 | Hyperglycemia | PhenotypicFeature |
| MESH:D003924 | Diabetes mellitus type 2 | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tolbutamide | DECREASES ACTIVITY OF | Atp-Binding Cassette Sub-Family C Member 8 |
| Atp-Binding Cassette Sub-Family C Member 8 | POSITIVELY CORRELATED WITH | Atp-Activated Inward Rectifier Potassium Channel Activity |
| Atp-Activated Inward Rectifier Potassium Channel Activity | NEGATIVELY CORRELATED WITH | Membrane Depolarization |
| Membrane Depolarization | POSITIVELY CORRELATED WITH | Calcium Ion Import |
| Calcium Ion Import | POSITIVELY CORRELATED WITH | Insulin Secretion |
| Insulin Secretion | NEGATIVELY CORRELATED WITH | Hyperglycemia |
| Hyperglycemia | MANIFESTATION OF | Diabetes Mellitus Type 2 |
Reference: