Path ID: DB01119_MESH_D046768_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D003981 | diazoxide | Drug |
| UniProt:Q14654 | ATP-sensitive inward rectifier potassium channel 11 | Protein |
| GO:0060081 | membrane hyperpolarization | BiologicalProcess |
| GO:0070509 | transmembrane calcium influx | BiologicalProcess |
| GO:0030073 | insulin secretion | BiologicalProcess |
| MESH:D006946 | Hyperinsulinism | Disease |
| MESH:D046768 | Islet cell hyperplasia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Diazoxide | INCREASES ACTIVITY OF | Atp-Sensitive Inward Rectifier Potassium Channel 11 |
| Atp-Sensitive Inward Rectifier Potassium Channel 11 | PARTICIPATES IN | Membrane Hyperpolarization |
| Membrane Hyperpolarization | NEGATIVELY REGULATES | Transmembrane Calcium Influx |
| Transmembrane Calcium Influx | POSITIVELY REGULATES | Insulin Secretion |
| Insulin Secretion | CONTRIBUTES TO | Hyperinsulinism |
| Hyperinsulinism | MANIFESTATION OF | Islet Cell Hyperplasia |
Reference: