Path ID: DB01117_MESH_D016778_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D053626 | Atovaquone | Drug |
| UniProt:Q02768 | Cytochrome b (Plasmodium falciparum) | Protein |
| UniProt:Q08210 | Dihydroorotate dehydrogenase (quinone), mitochondrial | Protein |
| GO:0042773 | ATP synthesis coupled electron transport | BiologicalProcess |
| GO:0019856 | Pyrimidine nucleobase biosynthetic process | BiologicalProcess |
| taxonomy:5833 | Plasmodium falciparum | OrganismTaxon |
| MESH:D016778 | Falciparum malaria | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Atovaquone | DECREASES ACTIVITY OF | Cytochrome B (Plasmodium Falciparum) |
| Atovaquone | DECREASES ACTIVITY OF | Dihydroorotate Dehydrogenase (Quinone), Mitochondrial |
| Cytochrome B (Plasmodium Falciparum) | POSITIVELY REGULATES | Atp Synthesis Coupled Electron Transport |
| Dihydroorotate Dehydrogenase (Quinone), Mitochondrial | POSITIVELY REGULATES | Pyrimidine Nucleobase Biosynthetic Process |
| Atp Synthesis Coupled Electron Transport | IN TAXON | Plasmodium Falciparum |
| Pyrimidine Nucleobase Biosynthetic Process | IN TAXON | Plasmodium Falciparum |
| Plasmodium Falciparum | CAUSES | Falciparum Malaria |
Reference: