Path ID: DB01116_MESH_D011654_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014294 | trimetaphan | Drug |
| UniProt:Q9GZZ6 | Neuronal acetylcholine receptor subunit alpha-10 | Protein |
| UniProt:P30926 | Neuronal acetylcholine receptor subunit beta-4 | Protein |
| UniProt:P32297 | Neuronal acetylcholine receptor subunit beta-3 | Protein |
| GO:0007271 | synaptic transmission, cholinergic | BiologicalProcess |
| GO:0044557 | smooth muscle relaxation | BiologicalProcess |
| GO:0042311 | vasodilation | BiologicalProcess |
| HP:0032263 | Increased blood pressure | PhenotypicFeature |
| MESH:D011654 | Pulmonary edema | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Trimetaphan | DECREASES ACTIVITY OF | Neuronal Acetylcholine Receptor Subunit Alpha-10 |
| Trimetaphan | DECREASES ACTIVITY OF | Neuronal Acetylcholine Receptor Subunit Beta-4 |
| Trimetaphan | DECREASES ACTIVITY OF | Neuronal Acetylcholine Receptor Subunit Beta-3 |
| Neuronal Acetylcholine Receptor Subunit Alpha-10 | POSITIVELY REGULATES | Synaptic Transmission, Cholinergic |
| Neuronal Acetylcholine Receptor Subunit Beta-4 | POSITIVELY REGULATES | Synaptic Transmission, Cholinergic |
| Neuronal Acetylcholine Receptor Subunit Beta-3 | POSITIVELY REGULATES | Synaptic Transmission, Cholinergic |
| Synaptic Transmission, Cholinergic | NEGATIVELY CORRELATED WITH | Smooth Muscle Relaxation |
| Smooth Muscle Relaxation | POSITIVELY CORRELATED WITH | Vasodilation |
| Vasodilation | NEGATIVELY CORRELATED WITH | Increased Blood Pressure |
| Increased Blood Pressure | POSITIVELY CORRELATED WITH | Pulmonary Edema |
Comment: Trimethaphan is indicated for production of controlled hypotension during surgery. During the emergency treatment of pulmonary edema in patients with pulmonary hypertension associated with systemic hypertension.
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