Path ID: DB01115_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D009543 | Nifedipine | Drug |
| UniProt:Q13936 | Voltage-dependent L-type calcium channel subunit alpha-1C | Protein |
| GO:0070509 | Transmembrane calcium influx | BiologicalProcess |
| GO:0045907 | Positive regulation of vasoconstriction | BiologicalProcess |
| GO:0008217 | Blood Pressure | BiologicalProcess |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Nifedipine | DECREASES ACTIVITY OF | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C |
| Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C | PARTICIPATES IN | Transmembrane Calcium Influx |
| Transmembrane Calcium Influx | CONTRIBUTES TO | Positive Regulation Of Vasoconstriction |
| Positive Regulation Of Vasoconstriction | POSITIVELY REGULATES | Blood Pressure |
| Blood Pressure | POSITIVELY CORRELATED WITH | Hypertensive Disorder |
Reference: