Path ID: DB01114_MESH_D003233_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D002744 | Chlorphenamine | Drug |
| UniProt:P35367 | Histamine H1 receptor | Protein |
| MESH:D006632 | Histamine | ChemicalSubstance |
| UniProt:P50148 | Guanine nucleotide-binding protein G(q) subunit alpha | Protein |
| UniProt:P19838 | Nuclear factor NF-kappa-B p105 subunit | Protein |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| HP:0000969 | Edema | PhenotypicFeature |
| MESH:D003233 | Allergic conjunctivitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Chlorphenamine | NEGATIVELY REGULATES | Histamine H1 Receptor |
| Histamine H1 Receptor | POSITIVELY CORRELATED WITH | Histamine |
| Histamine | POSITIVELY REGULATES | Guanine Nucleotide-Binding Protein G(Q) Subunit Alpha |
| Guanine Nucleotide-Binding Protein G(Q) Subunit Alpha | POSITIVELY REGULATES | Nuclear Factor Nf-Kappa-B P105 Subunit |
| Nuclear Factor Nf-Kappa-B P105 Subunit | POSITIVELY REGULATES | Inflammatory Response |
| Inflammatory Response | CONTRIBUTES TO | Edema |
| Edema | OCCURS IN | Allergic Conjunctivitis |
Reference: