Path ID: DB01110_MESH_D014009_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008825 | miconazole | Drug |
| InterPro:IPR001128 | Cytochrome P450 | GeneFamily |
| GO:0006696 | ergosterol biosynthetic process | BiologicalProcess |
| taxonomy:5551 | Trichophyton rubrum | OrganismTaxon |
| MESH:D014009 | Onychomycosis due to dermatophyte | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Miconazole | NEGATIVELY REGULATES | Cytochrome P450 |
| Cytochrome P450 | POSITIVELY REGULATES | Ergosterol Biosynthetic Process |
| Ergosterol Biosynthetic Process | IN TAXON | Trichophyton Rubrum |
| Trichophyton Rubrum | CAUSES | Onychomycosis Due To Dermatophyte |
Comment: In addition to its antifungal actions, miconazole has antiglucocorticoid effects (https://pubmed.ncbi.nlm.nih.gov/16608920/).
Reference: