Path ID: DB01110_MESH_D002181_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008825 | miconazole | Drug |
| UniProt:P10613 | Lanosterol 14-alpha demethylase | Protein |
| GO:0006696 | ergosterol biosynthetic process | BiologicalProcess |
| taxonomy:237561 | Candida albicans SC5314 | OrganismTaxon |
| MESH:D002181 | Candidal vulvovaginitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Miconazole | NEGATIVELY REGULATES | Lanosterol 14-Alpha Demethylase |
| Lanosterol 14-Alpha Demethylase | POSITIVELY REGULATES | Ergosterol Biosynthetic Process |
| Ergosterol Biosynthetic Process | IN TAXON | Candida Albicans Sc5314 |
| Candida Albicans Sc5314 | CAUSES | Candidal Vulvovaginitis |
Comment: In addition to its antifungal actions, miconazole has antiglucocorticoid effects (https://pubmed.ncbi.nlm.nih.gov/16608920/).
Reference: