Path ID: DB01097_MESH_D001172_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C045463 | Leflunomide | Drug |
| MESH:C527525 | Teriflunomide | Drug |
| UniProt:Q02127 | Dihydroorotate dehydrogenase (quinone), mitochondrial | Protein |
| GO:0006221 | Pyrimidine nucleotide biosynthetic process | BiologicalProcess |
| GO:0090592 | DNA synthesis involved in DNA replication | BiologicalProcess |
| GO:0050798 | Activated T cell proliferation | BiologicalProcess |
| MESH:D001172 | Rheumatoid arthritis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Leflunomide | HAS METABOLITE | Teriflunomide |
| Teriflunomide | DECREASES ACTIVITY OF | Dihydroorotate Dehydrogenase (Quinone), Mitochondrial |
| Dihydroorotate Dehydrogenase (Quinone), Mitochondrial | POSITIVELY REGULATES | Pyrimidine Nucleotide Biosynthetic Process |
| Pyrimidine Nucleotide Biosynthetic Process | POSITIVELY CORRELATED WITH | Dna Synthesis Involved In Dna Replication |
| Dna Synthesis Involved In Dna Replication | POSITIVELY CORRELATED WITH | Activated T Cell Proliferation |
| Activated T Cell Proliferation | POSITIVELY CORRELATED WITH | Rheumatoid Arthritis |
Reference: