Path ID: DB01088_MESH_D000081029_1

Concepts
Identifier | Name | Type |
---|---|---|
MESH:D016285 | iloprost | Drug |
UniProt:P43119 | Prostacyclin receptor | Protein |
UniProt:P34995 | Prostaglandin E2 receptor EP1 subtype | Protein |
UniProt:P43116 | Prostaglandin E2 receptor EP2 subtype | Protein |
UniProt:P35408 | Prostaglandin E2 receptor EP4 subtype | Protein |
UniProt:Q9Y5Y4 | Prostaglandin D2 receptor 2 | Protein |
MESH:D002118 | Calcium | ChemicalSubstance |
GO:0044557 | relaxation of smooth muscle | BiologicalProcess |
GO:0042311 | vasodilation | BiologicalProcess |
MESH:D000081029 | Pulmonary arterial hypertension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
Subject | Predicate | Object |
---|---|---|
Iloprost | INCREASES ACTIVITY OF | Prostacyclin Receptor |
Iloprost | INCREASES ACTIVITY OF | Prostaglandin E2 Receptor Ep1 Subtype |
Iloprost | INCREASES ACTIVITY OF | Prostaglandin E2 Receptor Ep2 Subtype |
Iloprost | INCREASES ACTIVITY OF | Prostaglandin E2 Receptor Ep4 Subtype |
Iloprost | INCREASES ACTIVITY OF | Prostaglandin D2 Receptor 2 |
Prostaglandin E2 Receptor Ep1 Subtype | DECREASES ABUNDANCE OF | Calcium |
Prostaglandin E2 Receptor Ep2 Subtype | DECREASES ABUNDANCE OF | Calcium |
Prostaglandin D2 Receptor 2 | DECREASES ABUNDANCE OF | Calcium |
Prostaglandin E2 Receptor Ep4 Subtype | DECREASES ABUNDANCE OF | Calcium |
Prostacyclin Receptor | DECREASES ABUNDANCE OF | Calcium |
Calcium | NEGATIVELY CORRELATED WITH | Relaxation Of Smooth Muscle |
Relaxation Of Smooth Muscle | POSITIVELY CORRELATED WITH | Vasodilation |
Vasodilation | NEGATIVELY CORRELATED WITH | Pulmonary Arterial Hypertension |
Reference:
- https://go.drugbank.com/drugs/DB01088#BE0000475
- https://en.wikipedia.org/wiki/Iloprost#Clinical_pharmacology
- https://en.wikipedia.org/wiki/Vasodilation#Examples_and_individual_mechanisms
- https://en.wikipedia.org/wiki/Prostacyclin#Mechanism
- https://en.wikipedia.org/wiki/Prostaglandin_EP3_receptor#Therapeutics