Path ID: DB01088_MESH_D000081029_1

db01088-mesh-d000081029-1

Concepts

Identifier Name Type
MESH:D016285 iloprost Drug
UniProt:P43119 Prostacyclin receptor Protein
UniProt:P34995 Prostaglandin E2 receptor EP1 subtype Protein
UniProt:P43116 Prostaglandin E2 receptor EP2 subtype Protein
UniProt:P35408 Prostaglandin E2 receptor EP4 subtype Protein
UniProt:Q9Y5Y4 Prostaglandin D2 receptor 2 Protein
MESH:D002118 Calcium ChemicalSubstance
GO:0044557 relaxation of smooth muscle BiologicalProcess
GO:0042311 vasodilation BiologicalProcess
MESH:D000081029 Pulmonary arterial hypertension Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Iloprost INCREASES ACTIVITY OF Prostacyclin Receptor
Iloprost INCREASES ACTIVITY OF Prostaglandin E2 Receptor Ep1 Subtype
Iloprost INCREASES ACTIVITY OF Prostaglandin E2 Receptor Ep2 Subtype
Iloprost INCREASES ACTIVITY OF Prostaglandin E2 Receptor Ep4 Subtype
Iloprost INCREASES ACTIVITY OF Prostaglandin D2 Receptor 2
Prostaglandin E2 Receptor Ep1 Subtype DECREASES ABUNDANCE OF Calcium
Prostaglandin E2 Receptor Ep2 Subtype DECREASES ABUNDANCE OF Calcium
Prostaglandin D2 Receptor 2 DECREASES ABUNDANCE OF Calcium
Prostaglandin E2 Receptor Ep4 Subtype DECREASES ABUNDANCE OF Calcium
Prostacyclin Receptor DECREASES ABUNDANCE OF Calcium
Calcium NEGATIVELY CORRELATED WITH Relaxation Of Smooth Muscle
Relaxation Of Smooth Muscle POSITIVELY CORRELATED WITH Vasodilation
Vasodilation NEGATIVELY CORRELATED WITH Pulmonary Arterial Hypertension

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