Path ID: DB01081_MESH_D003967_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004157 | diphenoxylate | Drug |
| DB:DB01501 | Difenoxin | ChemicalSubstance |
| UniProt:P35372 | Mu-type opioid receptor | Protein |
| GO:0120054 | intestinal motility | BiologicalProcess |
| MESH:D003967 | Diarrhea | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Diphenoxylate | HAS METABOLITE | Difenoxin |
| Difenoxin | INCREASES ACTIVITY OF | Mu-Type Opioid Receptor |
| Mu-Type Opioid Receptor | NEGATIVELY REGULATES | Intestinal Motility |
| Intestinal Motility | POSITIVELY CORRELATED WITH | Diarrhea |
Comment: Diphenoxylic acid (or difenoxin) is the pharmacologically active metabolite of diphenoxylate (https://pubmed.ncbi.nlm.nih.gov/3682841/), being 5 times more potent (https://pharmaceutical-journal.com/article/ld/understanding-the-chemical-basis-of-drug-stability-and-degradation). Diphenoxylate is rapidly metabolized to difenoxin (https://en.wikipedia.org/wiki/Diphenoxylate#Pharmacology). It’s been suggested that difenoxin may regulate non-opioid receptor pathways as well (https://go.drugbank.com/drugs/DB01501#mechanism-of-action).
Reference: