Path ID: DB01077_MESH_D010001_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D012968 | etidronic acid | Drug |
| GO:0140603 | ATP hydrolysis activity | MolecularActivity |
| UniProt:P38606 | V-type proton ATPase catalytic subunit A | Protein |
| GO:1902600 | proton transmembrane transport | BiologicalProcess |
| CHEBI:52255 | hydroxylapatite | ChemicalSubstance |
| CL:0000092 | osteoclast | Cell |
| GO:0045453 | bone resorption | BiologicalProcess |
| GO:0006915 | apoptotic process | BiologicalProcess |
| GO:0001503 | ossification | BiologicalProcess |
| GO:1990523 | bone regeneration | BiologicalProcess |
| MESH:D010001 | Osteitis deformans | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Etidronic Acid | NEGATIVELY CORRELATED WITH | Atp Hydrolysis Activity |
| Atp Hydrolysis Activity | INCREASES ACTIVITY OF | Osteoclast |
| Etidronic Acid | NEGATIVELY REGULATES | V-Type Proton Atpase Catalytic Subunit A |
| V-Type Proton Atpase Catalytic Subunit A | POSITIVELY REGULATES | Proton Transmembrane Transport |
| Proton Transmembrane Transport | POSITIVELY CORRELATED WITH | Bone Resorption |
| Etidronic Acid | POSITIVELY REGULATES | Apoptotic Process |
| Apoptotic Process | DECREASES ABUNDANCE OF | Osteoclast |
| Osteoclast | POSITIVELY REGULATES | Bone Resorption |
| Bone Resorption | POSITIVELY CORRELATED WITH | Osteitis Deformans |
| Etidronic Acid | MOLECULARLY INTERACTS WITH | Hydroxylapatite |
| Hydroxylapatite | POSITIVELY CORRELATED WITH | Ossification |
| Hydroxylapatite | POSITIVELY CORRELATED WITH | Bone Regeneration |
| Bone Regeneration | NEGATIVELY CORRELATED WITH | Osteitis Deformans |
| Ossification | NEGATIVELY CORRELATED WITH | Osteitis Deformans |
Comment: Etidronate is a weak inhibitor of proton transport in animal models (https://pubmed.ncbi.nlm.nih.gov/8889850/).
Reference: