Path ID: DB01065_MESH_D007319_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008550 | melatonin | Drug |
| UniProt:P48039 | Melatonin receptor type 1A | Protein |
| UniProt:P49286 | Melatonin receptor type 1B | Protein |
| UBERON:0002034 | suprachiasmatic nucleus | GrossAnatomicalStructure |
| UniProt:B7Z2C7 | Adenylate cyclase | Protein |
| CHEBI:17489 | 3’,5’-cyclic AMP | ChemicalSubstance |
| GO:0022410 | circadian sleep/wake cycle process | BiologicalProcess |
| MESH:D007319 | Disorders of initiating and maintaining sleep | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Melatonin | POSITIVELY REGULATES | Melatonin Receptor Type 1A |
| Melatonin | POSITIVELY REGULATES | Melatonin Receptor Type 1B |
| Melatonin Receptor Type 1A | LOCATED IN | Suprachiasmatic Nucleus |
| Melatonin Receptor Type 1B | LOCATED IN | Suprachiasmatic Nucleus |
| Melatonin Receptor Type 1A | DECREASES ACTIVITY OF | Adenylate Cyclase |
| Adenylate Cyclase | INCREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| Melatonin Receptor Type 1B | DECREASES ACTIVITY OF | Adenylate Cyclase |
| Adenylate Cyclase | INCREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| Suprachiasmatic Nucleus | PARTICIPATES IN | Circadian Sleep/Wake Cycle Process |
| 3’,5’-Cyclic Amp | NEGATIVELY REGULATES | Circadian Sleep/Wake Cycle Process |
| Circadian Sleep/Wake Cycle Process | NEGATIVELY CORRELATED WITH | Disorders Of Initiating And Maintaining Sleep |
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