Path ID: DB01064_MESH_D012769_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D007545 | Isoprenaline | Drug |
| UniProt:P08588 | Beta-1 adrenergic receptor | Protein |
| UniProt:P07550 | Beta-2 adrenergic receptor | Protein |
| UniProt:P13945 | Beta-3 adrenergic receptor | Protein |
| UniProt:B7Z2C7 | Adenylate cyclase | Protein |
| CHEBI:17489 | 3’,5’-cyclic AMP | ChemicalSubstance |
| GO:0060047 | Heart contraction | BiologicalProcess |
| HP:0033532 | Decreased cardiac output | PhenotypicFeature |
| MESH:D012769 | Hypovolemic shock | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Isoprenaline | INCREASES ACTIVITY OF | Beta-1 Adrenergic Receptor |
| Isoprenaline | INCREASES ACTIVITY OF | Beta-2 Adrenergic Receptor |
| Isoprenaline | INCREASES ACTIVITY OF | Beta-3 Adrenergic Receptor |
| Beta-1 Adrenergic Receptor | INCREASES ACTIVITY OF | Adenylate Cyclase |
| Beta-2 Adrenergic Receptor | INCREASES ACTIVITY OF | Adenylate Cyclase |
| Beta-3 Adrenergic Receptor | INCREASES ACTIVITY OF | Adenylate Cyclase |
| Adenylate Cyclase | INCREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| 3’,5’-Cyclic Amp | POSITIVELY REGULATES | Heart Contraction |
| Heart Contraction | NEGATIVELY CORRELATED WITH | Decreased Cardiac Output |
| Decreased Cardiac Output | POSITIVELY CORRELATED WITH | Hypovolemic Shock |
Reference: