Path ID: DB010473_MESH_D003876_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D005447 | Fluocinonide | Drug |
| UniProt:P04150 | Glucocorticoid receptor | Protein |
| UniProt:P04083 | Annexin A1 | Protein |
| UniProt:P47712 | Cytosolic phospholipase A2 | Protein |
| UniProt:P35354 | Prostaglandin G/H synthase 2 | Protein |
| MESH:D011453 | Prostaglandins | ChemicalSubstance |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| HP:0000989 | Pruritus | PhenotypicFeature |
| HP:0000969 | Edema | PhenotypicFeature |
| MESH:D003876 | Atopic dermatitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Fluocinonide | INCREASES ACTIVITY OF | Glucocorticoid Receptor |
| Glucocorticoid Receptor | INCREASES ACTIVITY OF | Annexin A1 |
| Annexin A1 | DECREASES ACTIVITY OF | Cytosolic Phospholipase A2 |
| Annexin A1 | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 2 |
| Cytosolic Phospholipase A2 | INCREASES ABUNDANCE OF | Prostaglandins |
| Prostaglandin G/H Synthase 2 | INCREASES ABUNDANCE OF | Prostaglandins |
| Prostaglandins | POSITIVELY REGULATES | Inflammatory Response |
| Inflammatory Response | HAS PHENOTYPE | Pruritus |
| Inflammatory Response | HAS PHENOTYPE | Edema |
| Pruritus | MANIFESTATION OF | Atopic Dermatitis |
| Edema | MANIFESTATION OF | Atopic Dermatitis |
Reference: