Path ID: DB01041_MESH_D009101_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D013792 | thalidomide | Drug |
| UniProt:P01375 | Tumor necrosis factor | Protein |
| UniProt:P15692 | Vascular endothelial growth factor A | Protein |
| UniProt:Q96SW2 | Protein cereblon | Protein |
| GO:0016567 | protein ubiquitination | BiologicalProcess |
| GO:0051301 | cell division | BiologicalProcess |
| GO:0001525 | angiogenesis | BiologicalProcess |
| GO:0008283 | cell population proliferation | BiologicalProcess |
| GO:0032635 | interleukin-6 production | BiologicalProcess |
| GO:0006954 | inflammatory response | BiologicalProcess |
| CHEBI:26523 | reactive oxygen species | ChemicalSubstance |
| GO:0036473 | cell death in response to oxidative stress | BiologicalProcess |
| GO:0002534 | cytokine production involved in inflammatory response | BiologicalProcess |
| MESH:D009101 | Multiple myeloma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Thalidomide | INCREASES ABUNDANCE OF | Reactive Oxygen Species |
| Reactive Oxygen Species | POSITIVELY CORRELATED WITH | Cell Death In Response To Oxidative Stress |
| Cell Death In Response To Oxidative Stress | NEGATIVELY CORRELATED WITH | Multiple Myeloma |
| Thalidomide | DECREASES ACTIVITY OF | Protein Cereblon |
| Protein Cereblon | POSITIVELY REGULATES | Protein Ubiquitination |
| Protein Ubiquitination | NEGATIVELY CORRELATED WITH | Cell Division |
| Cell Division | POSITIVELY CORRELATED WITH | Cell Population Proliferation |
| Thalidomide | DECREASES ACTIVITY OF | Tumor Necrosis Factor |
| Thalidomide | DECREASES ACTIVITY OF | Vascular Endothelial Growth Factor A |
| Tumor Necrosis Factor | POSITIVELY REGULATES | Cell Population Proliferation |
| Tumor Necrosis Factor | POSITIVELY REGULATES | Interleukin-6 Production |
| Interleukin-6 Production | POSITIVELY REGULATES | Inflammatory Response |
| Tumor Necrosis Factor | POSITIVELY REGULATES | Cytokine Production Involved In Inflammatory Response |
| Vascular Endothelial Growth Factor A | POSITIVELY REGULATES | Angiogenesis |
| Angiogenesis | POSITIVELY CORRELATED WITH | Multiple Myeloma |
| Cell Population Proliferation | POSITIVELY CORRELATED WITH | Multiple Myeloma |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Multiple Myeloma |
| Cytokine Production Involved In Inflammatory Response | POSITIVELY CORRELATED WITH | Multiple Myeloma |
Comment: The precise mechanism of action for thalidomide is unknown (https://en.wikipedia.org/wiki/Thalidomide#Pharmacology).
Reference: