Path ID: DB01039_MESH_D006937_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D011345 | Fenofibrate | Drug |
| MESH:C006012 | Fenofibric acid | Drug |
| UniProt:Q07869 | Peroxisome proliferator-activated receptor alpha | Protein |
| MESH:D008075 | Lipoproteins, HDL | ChemicalSubstance |
| MESH:D015243 | Cholesterol, VLDL | ChemicalSubstance |
| MESH:D006937 | Hypercholesterolemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Fenofibrate | HAS METABOLITE | Fenofibric Acid |
| Fenofibric Acid | INCREASES ACTIVITY OF | Peroxisome Proliferator-Activated Receptor Alpha |
| Peroxisome Proliferator-Activated Receptor Alpha | INCREASES ABUNDANCE OF | Lipoproteins, Hdl |
| Peroxisome Proliferator-Activated Receptor Alpha | DECREASES ABUNDANCE OF | Cholesterol, Vldl |
| Lipoproteins, Hdl | NEGATIVELY CORRELATED WITH | Hypercholesterolemia |
| Cholesterol, Vldl | POSITIVELY CORRELATED WITH | Hypercholesterolemia |
Comment: Fenofibrate is pharmacologically inactive prodrug which undergoes rapid hydrolysis at the ester bond to form the active metabolite fenofibric acid.
Reference: