Path ID: DB01037_MESH_D010300_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D012642 | selegiline | Drug |
| UniProt:P21397 | Amine oxidase [flavin-containing] A | Protein |
| UniProt:P27338 | Amine oxidase [flavin-containing] B | Protein |
| MESH:D004298 | Dopamine | ChemicalSubstance |
| GO:0042420 | dopamine catabolic process | BiologicalProcess |
| GO:0001963 | synaptic transmission, dopaminergic | BiologicalProcess |
| MESH:D010300 | Parkinson’s disease | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Selegiline | NEGATIVELY REGULATES | Amine Oxidase [Flavin-Containing] B |
| Selegiline | NEGATIVELY REGULATES | Amine Oxidase [Flavin-Containing] A |
| Amine Oxidase [Flavin-Containing] B | POSITIVELY REGULATES | Dopamine Catabolic Process |
| Amine Oxidase [Flavin-Containing] A | POSITIVELY REGULATES | Dopamine Catabolic Process |
| Dopamine Catabolic Process | DECREASES ABUNDANCE OF | Dopamine |
| Dopamine | POSITIVELY CORRELATED WITH | Synaptic Transmission, Dopaminergic |
| Synaptic Transmission, Dopaminergic | NEGATIVELY CORRELATED WITH | Parkinson’S Disease |
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