Path ID: DB01033_MESH_D015473_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D015122 | Mercaptopurine | Drug |
| UniProt:P00492 | Hypoxanthine-guanine phosphoribosyltransferase | Protein |
| UniProt:Q06203 | Amidophosphoribosyltransferase | Protein |
| UniProt:P20839 | Inosine-5’-monophosphate dehydrogenase 1 | Protein |
| UniProt:P12268 | Inosine-5’-monophosphate dehydrogenase 2 | Protein |
| CL:0000836 | Promyelocyte | Cell |
| GO:0006164 | Purine nucleotide biosynthetic process | BiologicalProcess |
| MESH:D015473 | Acute promyelocytic leukemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Mercaptopurine | DECREASES ACTIVITY OF | Hypoxanthine-Guanine Phosphoribosyltransferase |
| Mercaptopurine | DECREASES ACTIVITY OF | Amidophosphoribosyltransferase |
| Mercaptopurine | DECREASES ACTIVITY OF | Inosine-5’-Monophosphate Dehydrogenase 1 |
| Mercaptopurine | DECREASES ACTIVITY OF | Inosine-5’-Monophosphate Dehydrogenase 2 |
| Hypoxanthine-Guanine Phosphoribosyltransferase | POSITIVELY REGULATES | Purine Nucleotide Biosynthetic Process |
| Amidophosphoribosyltransferase | POSITIVELY REGULATES | Purine Nucleotide Biosynthetic Process |
| Inosine-5’-Monophosphate Dehydrogenase 1 | POSITIVELY REGULATES | Purine Nucleotide Biosynthetic Process |
| Inosine-5’-Monophosphate Dehydrogenase 2 | POSITIVELY REGULATES | Purine Nucleotide Biosynthetic Process |
| Purine Nucleotide Biosynthetic Process | OCCURS IN | Promyelocyte |
| Promyelocyte | POSITIVELY CORRELATED WITH | Acute Promyelocytic Leukemia |
Reference: