Path ID: DB01026_MESH_D000308_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D007654 | ketoconazole | Drug |
| UniProt:P05093 | Steroid 17-alpha-hydroxylase/17,20 lyase | Protein |
| GO:0006704 | glucocorticoid biosynthetic process | BiologicalProcess |
| MESH:D005938 | Glucocorticoids | ChemicalSubstance |
| MESH:D000308 | Adrenocortical Hyperfunction | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ketoconazole | DECREASES ACTIVITY OF | Steroid 17-Alpha-Hydroxylase/17,20 Lyase |
| Steroid 17-Alpha-Hydroxylase/17,20 Lyase | POSITIVELY REGULATES | Glucocorticoid Biosynthetic Process |
| Glucocorticoid Biosynthetic Process | INCREASES ABUNDANCE OF | Glucocorticoids |
| Glucocorticoids | POSITIVELY CORRELATED WITH | Adrenocortical Hyperfunction |
Reference: