Path ID: DB01022_MESH_D015663_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014812 | Phytomenadione | Drug |
| UniProt:P02818 | Osteocalcin | Protein |
| GO:0030282 | Bone mineralization | BiologicalProcess |
| MESH:D015663 | Postmenopausal osteoporosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Phytomenadione | INCREASES ACTIVITY OF | Osteocalcin |
| Osteocalcin | POSITIVELY REGULATES | Bone Mineralization |
| Bone Mineralization | NEGATIVELY CORRELATED WITH | Postmenopausal Osteoporosis |
Comment: Phytomenadione promotes calcification of bones and can be supplemented together with calcium sources in cases of postmenopausal osteoporosis. Additionally phytomenadione may prevent arterial calcification in case of calcium supplementation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566462/
Reference: