Path ID: DB01020_MESH_D000787_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C030397 | isosorbide mononitrate | Drug |
| MESH:D009569 | Nitric oxide | ChemicalSubstance |
| InterPro:IPR001170 | Guanylate cyclase | GeneFamily |
| GO:0051208 | Sequestering of calcium ion | BiologicalProcess |
| GO:0042311 | Vasodilation | BiologicalProcess |
| MESH:D006152 | Cyclic guanosine 3’,5’-monophosphate (cGMP) | ChemicalSubstance |
| GO:0006470 | Protein dephosphorylation | BiologicalProcess |
| MESH:D018994 | Myosin light chains | ChemicalSubstance |
| GO:0060087 | Relaxation of vascular associated smooth muscle | BiologicalProcess |
| MESH:D000787 | Angina pectoris | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Isosorbide Mononitrate | INCREASES ABUNDANCE OF | Nitric Oxide |
| Nitric Oxide | POSITIVELY REGULATES | Guanylate Cyclase |
| Guanylate Cyclase | INCREASES ACTIVITY OF | Cyclic Guanosine 3’,5’-Monophosphate (Cgmp) |
| Cyclic Guanosine 3’,5’-Monophosphate (Cgmp) | POSITIVELY REGULATES | Protein Dephosphorylation |
| Cyclic Guanosine 3’,5’-Monophosphate (Cgmp) | POSITIVELY REGULATES | Sequestering Of Calcium Ion |
| Sequestering Of Calcium Ion | POSITIVELY CORRELATED WITH | Relaxation Of Vascular Associated Smooth Muscle |
| Sequestering Of Calcium Ion | PRECEDES | Vasodilation |
| Vasodilation | AMELIORATES | Angina Pectoris |
| Protein Dephosphorylation | OCCURS IN | Myosin Light Chains |
| Myosin Light Chains | POSITIVELY CORRELATED WITH | Relaxation Of Vascular Associated Smooth Muscle |
| Relaxation Of Vascular Associated Smooth Muscle | AMELIORATES | Angina Pectoris |
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