Path ID: DB01018_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D016316 | Guanfacine | Drug |
| UniProt:P08913 | Alpha-2A adrenergic receptor | Protein |
| GO:0004938 | Alpha2-adrenergic receptor activity | BiologicalProcess |
| GO:0061533 | Norepinephrine secretion, neurotransmission | BiologicalProcess |
| HP:0032263 | Increased blood pressure | PhenotypicFeature |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Guanfacine | INCREASES ACTIVITY OF | Alpha-2A Adrenergic Receptor |
| Alpha-2A Adrenergic Receptor | POSITIVELY CORRELATED WITH | Alpha2-Adrenergic Receptor Activity |
| Alpha2-Adrenergic Receptor Activity | NEGATIVELY REGULATES | Norepinephrine Secretion, Neurotransmission |
| Norepinephrine Secretion, Neurotransmission | POSITIVELY CORRELATED WITH | Increased Blood Pressure |
| Increased Blood Pressure | POSITIVELY CORRELATED WITH | Hypertensive Disorder |
Reference: