Path ID: DB01016_MESH_D003924_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D005905 | glibenclamide | Drug |
| UniProt:Q14654 | ATP-sensitive inward rectifier potassium channel 11 | Protein |
| UniProt:Q09428 | ATP-binding cassette sub-family C member 8 | Protein |
| GO:0060081 | Membrane hyperpolarization | BiologicalProcess |
| GO:0070509 | Transmembrane calcium influx | BiologicalProcess |
| GO:0030073 | Insulin secretion | BiologicalProcess |
| HP:0003074 | Hyperglycemia | PhenotypicFeature |
| MESH:D003924 | Diabetes mellitus type 2 | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Glibenclamide | DECREASES ACTIVITY OF | Atp-Sensitive Inward Rectifier Potassium Channel 11 |
| Atp-Sensitive Inward Rectifier Potassium Channel 11 | PARTICIPATES IN | Membrane Hyperpolarization |
| Glibenclamide | DECREASES ACTIVITY OF | Atp-Binding Cassette Sub-Family C Member 8 |
| Atp-Binding Cassette Sub-Family C Member 8 | PARTICIPATES IN | Membrane Hyperpolarization |
| Membrane Hyperpolarization | NEGATIVELY REGULATES | Transmembrane Calcium Influx |
| Transmembrane Calcium Influx | POSITIVELY REGULATES | Insulin Secretion |
| Insulin Secretion | NEGATIVELY CORRELATED WITH | Hyperglycemia |
| Hyperglycemia | MANIFESTATION OF | Diabetes Mellitus Type 2 |
Comment: glibenclamide is alo known as Glyburide and is a sulfonylurea-type anti-diabetic drug.
Reference: