Path ID: DB01014_MESH_D003093_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C038637 | balsalazide | Drug |
| MESH:D019804 | Mesalamine | ChemicalSubstance |
| UniProt:P23219 | Prostaglandin G/H synthase 1 | Protein |
| UniProt:P35354 | Prostaglandin G/H synthase 2 | Protein |
| UniProt:P09917 | Polyunsaturated fatty acid 5-lipoxygenase | Protein |
| UniProt:P37231 | Peroxisome proliferator-activated receptor gamma | Protein |
| UniProt:O15111 | Inhibitor of nuclear factor kappa-B kinase subunit alpha | Protein |
| UniProt:O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | Protein |
| GO:0007249 | I-kappaB kinase/NF-kappaB signaling | BiologicalProcess |
| reactome:R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | Pathway |
| reactome:R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | Pathway |
| reactome:R-HSA-1169091 | Activation of NF-kappaB in B cells | Pathway |
| GO:0006954 | inflammatory response | BiologicalProcess |
| UBERON:0001052 | rectum | GrossAnatomicalStructure |
| UBERON:0001155 | colon | GrossAnatomicalStructure |
| MESH:D003093 | Ulcerative colitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Balsalazide | HAS METABOLITE | Mesalamine |
| Mesalamine | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 2 |
| Mesalamine | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 1 |
| Mesalamine | DECREASES ACTIVITY OF | Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Alpha |
| Mesalamine | DECREASES ACTIVITY OF | Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Beta |
| Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Beta | POSITIVELY REGULATES | I-Kappab Kinase/Nf-Kappab Signaling |
| Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Alpha | POSITIVELY REGULATES | I-Kappab Kinase/Nf-Kappab Signaling |
| I-Kappab Kinase/Nf-Kappab Signaling | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Mesalamine | DECREASES ACTIVITY OF | Polyunsaturated Fatty Acid 5-Lipoxygenase |
| Mesalamine | INCREASES ACTIVITY OF | Peroxisome Proliferator-Activated Receptor Gamma |
| Peroxisome Proliferator-Activated Receptor Gamma | NEGATIVELY CORRELATED WITH | Activation Of Nf-Kappab In B Cells |
| Activation Of Nf-Kappab In B Cells | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Polyunsaturated Fatty Acid 5-Lipoxygenase | PARTICIPATES IN | Synthesis Of Leukotrienes (Lt) And Eoxins (Ex) |
| Prostaglandin G/H Synthase 2 | PARTICIPATES IN | Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) |
| Prostaglandin G/H Synthase 1 | PARTICIPATES IN | Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) |
| Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Synthesis Of Leukotrienes (Lt) And Eoxins (Ex) | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Inflammatory Response | LOCATED IN | Rectum |
| Inflammatory Response | LOCATED IN | Colon |
| Rectum | LOCATION OF | Ulcerative Colitis |
| Colon | LOCATION OF | Ulcerative Colitis |
Comment: Balsalazide is a prodrug and it releases mesalazine in the large intestine, the active site of ulcerative colitis (https://en.wikipedia.org/wiki/Balsalazide https://en.wikipedia.org/wiki/Mesalazine#Chemistry)..)
Reference:
- https://go.drugbank.com/drugs/DB01014#mechanism-of-action
- https://go.drugbank.com/drugs/DB00244#mechanism-of-action
- https://pubmed.ncbi.nlm.nih.gov/20151072/
- https://go.drugbank.com/drugs/DB00244#BE0004655
- https://en.wikipedia.org/wiki/CHUK#Clinical_significance
- https://en.wikipedia.org/wiki/IKK2#Clinical_significance