Path ID: DB01009_MESH_D001172_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D007660 | ketoprofen | Drug |
| UniProt:P25024 | C-X-C chemokine receptor type 1 | Protein |
| GO:0030593 | neutrophil chemotaxis | BiologicalProcess |
| GO:0002407 | dendritic cell chemotaxis | BiologicalProcess |
| HP:0005059 | Arthralgia/arthritis | PhenotypicFeature |
| HP:0001386 | Joint swelling | PhenotypicFeature |
| GO:0006954 | inflammatory response | BiologicalProcess |
| MESH:D001172 | Rheumatoid arthritis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ketoprofen | NEGATIVELY REGULATES | C-X-C Chemokine Receptor Type 1 |
| C-X-C Chemokine Receptor Type 1 | POSITIVELY REGULATES | Neutrophil Chemotaxis |
| C-X-C Chemokine Receptor Type 1 | POSITIVELY REGULATES | Dendritic Cell Chemotaxis |
| Neutrophil Chemotaxis | POSITIVELY CORRELATED WITH | Arthralgia/Arthritis |
| Neutrophil Chemotaxis | POSITIVELY CORRELATED WITH | Joint Swelling |
| Dendritic Cell Chemotaxis | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Rheumatoid Arthritis |
| Arthralgia/Arthritis | POSITIVELY CORRELATED WITH | Rheumatoid Arthritis |
| Joint Swelling | POSITIVELY CORRELATED WITH | Rheumatoid Arthritis |
Reference: