Path ID: DB01009_MESH_D001172_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D007660 | ketoprofen | Drug |
| UniProt:P23219 | Prostaglandin G/H synthase 1 | Protein |
| UniProt:P35354 | Prostaglandin G/H synthase 2 | Protein |
| reactome:R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | Pathway |
| MESH:D011453 | Prostaglandins | ChemicalSubstance |
| HP:0005059 | Arthralgia/arthritis | PhenotypicFeature |
| HP:0001386 | Joint swelling | PhenotypicFeature |
| MESH:D001172 | Rheumatoid arthritis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ketoprofen | NEGATIVELY REGULATES | Prostaglandin G/H Synthase 1 |
| Ketoprofen | NEGATIVELY REGULATES | Prostaglandin G/H Synthase 2 |
| Prostaglandin G/H Synthase 1 | PARTICIPATES IN | Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) |
| Prostaglandin G/H Synthase 2 | PARTICIPATES IN | Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) |
| Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) | INCREASES ABUNDANCE OF | Prostaglandins |
| Prostaglandins | POSITIVELY CORRELATED WITH | Arthralgia/Arthritis |
| Prostaglandins | POSITIVELY CORRELATED WITH | Joint Swelling |
| Joint Swelling | POSITIVELY CORRELATED WITH | Rheumatoid Arthritis |
| Arthralgia/Arthritis | POSITIVELY CORRELATED WITH | Rheumatoid Arthritis |
Reference: